BDBM562235 1-([1,1′-bi(cyclopropan)]-1-yl)-5-(cyclobutylmethyl)-5,6,7,9-tetrahydro-4H-pyrano[4,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-one::US11401274, Example 5

SMILES O=c1n(CC2CCC2)c2CCOCc2n2c(nnc12)C1(CC1)C1CC1

InChI Key InChIKey=YXBLPELQAKXZRS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 562235   

LigandPNGBDBM562235(US11401274, Example 5 | 1-([1,1′-bi(cyclopro...)
Affinity DataIC50: 5.80nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent

LigandPNGBDBM562235(US11401274, Example 5 | 1-([1,1′-bi(cyclopro...)
Affinity DataIC50: 4.20nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent

LigandPNGBDBM562235(US11401274, Example 5 | 1-([1,1′-bi(cyclopro...)
Affinity DataIC50: 0nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Eli Lilly

US Patent
LigandPNGBDBM562235(US11401274, Example 5 | 1-([1,1′-bi(cyclopro...)
Affinity DataIC50: 1.00E+5nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Eli Lilly

US Patent
LigandPNGBDBM562235(US11401274, Example 5 | 1-([1,1′-bi(cyclopro...)
Affinity DataIC50: 1.92E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent

LigandPNGBDBM562235(US11401274, Example 5 | 1-([1,1′-bi(cyclopro...)
Affinity DataIC50: 1.00E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent