BDBM562108 7-(3-[4,4-bis(hydroxymethyl)-1-piperidinyl]propoxy)-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinazoline ::US11401260, Compound 1

SMILES COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCC(CO)(CO)CC1

InChI Key InChIKey=BMTDMPCSMBKKPW-UHFFFAOYSA-N

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 562108   

TargetVascular endothelial growth factor receptor 2(Human)
Kala Pharmaceuticals

US Patent
LigandPNGBDBM562108(US11401260, Compound 1 | 7-(3-[4,4-bis(hydroxymeth...)
Affinity DataKd:  0.380nMAssay Description:A competition binding assay, was used to measure the ability of a compound to compete for binding of an immobilized adenosine triphosphate (ATP) site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
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TargetIsoform 2 of Proto-oncogene tyrosine-protein kinase receptor Ret(Human)
Kala Pharmaceuticals

US Patent
LigandPNGBDBM562108(US11401260, Compound 1 | 7-(3-[4,4-bis(hydroxymeth...)
Affinity DataKd:  3.90nMAssay Description:A competition binding assay, was used to measure the ability of a compound to compete for binding of an immobilized adenosine triphosphate (ATP) site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent