BDBM561249 (3,3- difluoroazetidin- 1-yl)(6-(4-((3- fluoro-4- (1H-pyrazol-4- yl)phenyl)amino) pyrimidin-2-yl)-1- methyl-1H-indol- 2-yl)methanone::US11390609, Compound TDI01905::US20230285393, Compound 011

SMILES Cn1c(cc2ccc(cc12)-c1nccc(Nc2ccc(-c3cn[nH]c3)c(F)c2)n1)C(=O)N1CC(F)(F)C1

InChI Key InChIKey=FUWZHYVIYCRXTA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 561249   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561249((3,3- difluoroazetidin- 1-yl)(6-(4-((3- fluoro-4- ...)
Affinity DataIC50: 9nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561249((3,3- difluoroazetidin- 1-yl)(6-(4-((3- fluoro-4- ...)
Affinity DataIC50: 2.30E+3nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2 [1-119](Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561249((3,3- difluoroazetidin- 1-yl)(6-(4-((3- fluoro-4- ...)
Affinity DataIC50: 9nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent