BDBM561223 (3, 3-difluoroazetidin- 1-yl)(6-(4-((3-fluoro- 4-(1H-pyrazol-4- yl)phenyl)ami- no)pyrimidn-2-yl)- 1H-indol-2- yl)methanone::US11390609, Compound TDI01842B::US20230285393, Compound 010

SMILES Fc1cc(Nc2ccnc(n2)-c2ccc3cc([nH]c3c2)C(=O)N2CC(F)(F)C2)ccc1-c1cn[nH]c1

InChI Key InChIKey=NZWSJJDZDFLOSB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 561223   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561223((3, 3-difluoroazetidin- 1-yl)(6-(4-((3-fluoro- 4-(...)
Affinity DataIC50: 61nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561223((3, 3-difluoroazetidin- 1-yl)(6-(4-((3-fluoro- 4-(...)
Affinity DataIC50: 2.77E+3nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2 [1-119](Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561223((3, 3-difluoroazetidin- 1-yl)(6-(4-((3-fluoro- 4-(...)
Affinity DataIC50: 61nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent