BDBM560670 US11384083, Example 2

SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2c(n1)N(C1CCCC1)C(=O)C21CC1

InChI Key InChIKey=FZPJYIIJUFGDEH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 560670   

LigandPNGBDBM560670(US11384083, Example 2)
Affinity DataIC50: 300nMAssay Description:CDK2/Cyclin E1 enzyme activity assays utilized full-length human CDK2 co-expressed as N-terminal GST-tagged protein with FLAG-Cyclin E1 in a baculovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
Go to US Patent

LigandPNGBDBM560670(US11384083, Example 2)
Affinity DataIC50: 102nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged full-length CDK2/Flag-tagged cyclinE1 expressed in baculovirus expression system using eIF4E-bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM560670(US11384083, Example 2)
Affinity DataIC50: 102nMAssay Description:Inhibition of CDK2 in human COV318 cells incubated for overnight in presence of phospho-Rb by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM560670(US11384083, Example 2)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CDK1 in human OVCAR3 cells incubated for 30 mins in presence of pNPM T199 by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed