BDBM560645 US11384066, Example 41

SMILES C[C@H](N1CC[C@](Cc2nc(Nc3cc(C)[nH]n3)ccc2F)(C[C@H]1C)C(O)=O)c1cccc(Cl)c1F

InChI Key InChIKey=OZFMHKGOJNRRMZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 560645   

TargetAurora kinase A(Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM560645(US11384066, Example 41)
Affinity DataIC50: 2.70nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent

TargetAurora kinase B(Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM560645(US11384066, Example 41)
Affinity DataIC50: 9.94E+3nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent