BDBM559946 N-(4-methyl-3-(6-((4-methyltetrahydro- 2H-pyran-4-yl)ethynyl)-5- morpholinopyridin-3-yl)phenyl)-2- (trifluoromethyl)isonicotinamide::US11377431, Example 55

SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cnc(C#CC2(C)CCOCC2)c(c1)N1CCOCC1

InChI Key InChIKey=MFVWCVIMGCDBFJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 559946   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM559946(US11377431, Example 55 | N-(4-methyl-3-(6-((4-meth...)
Affinity DataIC50: 5.5nMAssay Description:Small molecule inhibition of the BRA and RAF kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
Go to US Patent