BDBM559939 N-(3-(6-(3-acetamidoprop-1-yn-1-yl)-5- morpholinopyridin-3-yl)-4- methylphenyl)-2- (trifluoromethyl)isonicotinamide::US11377431, Example 48

SMILES CC(=O)NCC#Cc1ncc(cc1N1CCOCC1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C

InChI Key InChIKey=UDXAPEXUBQDLIY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 559939   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM559939(US11377431, Example 48 | N-(3-(6-(3-acetamidoprop-...)
Affinity DataIC50: 1nMAssay Description:Small molecule inhibition of the BRA and RAF kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test ...More data for this Ligand-Target Pair
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Date in BDB:
10/5/2022
Entry Details
Go to US Patent