BDBM559938 N-(4-methyl-3-(6-((1- (methylsulfonyl)piperidin-4-yl)ethynyl)- 5-morpholinopyridin-3-yl)phenyl)-2- (trifluoromethyl)isonicotinamide::US11377431, Example 47

SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cnc(C#CC2CCN(CC2)S(C)(=O)=O)c(c1)N1CCOCC1

InChI Key InChIKey=HEVBXMPQNTYZGP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 559938   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM559938(US11377431, Example 47 | N-(4-methyl-3-(6-((1- (me...)
Affinity DataIC50: 1nMAssay Description:Small molecule inhibition of the BRA and RAF kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test ...More data for this Ligand-Target Pair
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Date in BDB:
10/5/2022
Entry Details
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