BDBM559936 N-(4-methyl-3-(5-morpholino-6- ((tetrahydrofuran-3-yl)ethynyl)pyridin-3- yl)phenyl)-2- (trifluoromethyl)isonicotinamide::US11377431, Example 45

SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cnc(C#CC2CCOC2)c(c1)N1CCOCC1

InChI Key InChIKey=LCDUWBASPANKKP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 559936   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM559936(US11377431, Example 45 | N-(4-methyl-3-(5-morpholi...)
Affinity DataIC50: 5.5nMAssay Description:Small molecule inhibition of the BRA and RAF kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test ...More data for this Ligand-Target Pair
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Date in BDB:
10/5/2022
Entry Details
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