BDBM559891 N-(3-{2-[(3S)-3-aminobut-1-yn-1-yl]-6- (morpholin-4-yl)pyridin-4-yl}-4- methylphenyl)-2- (trifluoromethyl)pyridine-4-carboxamide::US11377431, Example 6

SMILES C[C@H](N)C#Cc1cc(cc(n1)N1CCOCC1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C

InChI Key InChIKey=LPPLWRRLYIZSOJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 559891   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM559891(US11377431, Example 6 | N-(3-{2-[(3S)-3-aminobut-1...)
Affinity DataIC50: 5.5nMAssay Description:Small molecule inhibition of the BRA and RAF kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
Go to US Patent