BDBM558974 US11370774, Compound 146g::US11708347, Compound 146g

SMILES Cc1ccc(cc1)S(=O)(=O)n1ccc2cc(COc3ccccc3CC(O)=O)cc(-c3cccc(CN)c3)c12

InChI Key InChIKey=YZRGIVLJZDQWDM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 558974   

TargetComplement factor D(Human)
Biocryst Pharmaceuticals

US Patent
LigandPNGBDBM558974(US11370774, Compound 146g | US11708347, Compound 1...)
Affinity DataIC50: 5.50E+3nMAssay Description:An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetComplement factor D(Human)
Biocryst Pharmaceuticals

US Patent
LigandPNGBDBM558974(US11370774, Compound 146g | US11708347, Compound 1...)
Affinity DataIC50: 5.50E+3nMAssay Description:An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used. For this assay Z-Lys-SBzl, 1....More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
Go to US Patent