BDBM558863 US11370770, Compound 6o

SMILES Cc1ccc2[nH]nc(-c3ccc(F)c(CO)c3)c2c1

InChI Key InChIKey=JQCLZZOGJRPXOR-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 558863   

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Northwestern University

US Patent
LigandPNGBDBM558863(US11370770, Compound 6o)
Affinity DataIC50: 1.00E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Northwestern University

US Patent
LigandPNGBDBM558863(US11370770, Compound 6o)
Affinity DataIC50: 390nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Northwestern University

US Patent
LigandPNGBDBM558863(US11370770, Compound 6o)
Affinity DataIC50: 750nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Northwestern University

US Patent
LigandPNGBDBM558863(US11370770, Compound 6o)
Affinity DataIC50: 4.00E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMAP kinase-activated protein kinase 2(Human)
Northwestern University

US Patent
LigandPNGBDBM558863(US11370770, Compound 6o)
Affinity DataIC50: 5.40E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMAP kinase-activated protein kinase 3(Human)
Northwestern University

US Patent
LigandPNGBDBM558863(US11370770, Compound 6o)
Affinity DataIC50: 6.00E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMAP kinase-activated protein kinase 5(Human)
Northwestern University

US Patent
LigandPNGBDBM558863(US11370770, Compound 6o)
Affinity DataIC50: 2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 6(Human)
Northwestern University

US Patent
LigandPNGBDBM558863(US11370770, Compound 6o)
Affinity DataIC50: 3.40E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 7(Human)
Northwestern University

US Patent
LigandPNGBDBM558863(US11370770, Compound 6o)
Affinity DataIC50: 4.90E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent