BDBM558862 US11370770, Compound 6n

SMILES OC(=O)c1ccc(cc1)-c1n[nH]c2ccc(cc12)C(F)(F)F

InChI Key InChIKey=PPEQKTNTCJOCHX-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 558862   

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Northwestern University

US Patent
LigandPNGBDBM558862(US11370770, Compound 6n)
Affinity DataIC50: 470nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Northwestern University

US Patent
LigandPNGBDBM558862(US11370770, Compound 6n)
Affinity DataIC50: 130nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Northwestern University

US Patent
LigandPNGBDBM558862(US11370770, Compound 6n)
Affinity DataIC50: 60nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Northwestern University

US Patent
LigandPNGBDBM558862(US11370770, Compound 6n)
Affinity DataIC50: 1.00E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMAP kinase-activated protein kinase 2(Human)
Northwestern University

US Patent
LigandPNGBDBM558862(US11370770, Compound 6n)
Affinity DataIC50: 2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMAP kinase-activated protein kinase 3(Human)
Northwestern University

US Patent
LigandPNGBDBM558862(US11370770, Compound 6n)
Affinity DataIC50: 2.90E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMAP kinase-activated protein kinase 5(Human)
Northwestern University

US Patent
LigandPNGBDBM558862(US11370770, Compound 6n)
Affinity DataIC50: 2.70E+4nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 6(Human)
Northwestern University

US Patent
LigandPNGBDBM558862(US11370770, Compound 6n)
Affinity DataIC50: 6.00E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 7(Human)
Northwestern University

US Patent
LigandPNGBDBM558862(US11370770, Compound 6n)
Affinity DataIC50: 2.00E+3nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent