BDBM558598 6-(5-chloro-2-methyl-1H-benzo[d]imidazol-6- yl)-N-(4-(4-(dimethylamino)piperazin-1-yl) phenyl)-[1,2,4]triazolo[4',3':1,6]pyrido [2,3-d]pyrimidin-2-amine::US11365196, Compound 78

SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3cc(-c4cc5[nH]c(C)nc5cc4Cl)c4nncn4c3n2)cc1

InChI Key InChIKey=DNVMOBIJTRAPCP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 558598   

TargetFibroblast growth factor receptor 1(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558598(6-(5-chloro-2-methyl-1H-benzo[d]imidazol-6- yl)-N-...)
Affinity DataIC50: 1.90nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558598(6-(5-chloro-2-methyl-1H-benzo[d]imidazol-6- yl)-N-...)
Affinity DataIC50: 29nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558598(6-(5-chloro-2-methyl-1H-benzo[d]imidazol-6- yl)-N-...)
Affinity DataIC50: 600nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent