BDBM558592 (4-((6-(2-chloro-3,5-dimethoxyphenyl)- [1,2,4]triazolo[4',3':1,6]pyrido[2,3-d] pyrimidin-2-yl)amino)phenyl)((3S,5R)-3, 5-dimethylpiperazin-1-yl)methanone::US11365196, Compound 59

SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(Nc3ccc(cc3)C(=O)N3C[C@H](C)N[C@H](C)C3)nc2n2cnnc12

InChI Key InChIKey=BRGNIALEUFSUFN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 558592   

TargetFibroblast growth factor receptor 1(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558592((4-((6-(2-chloro-3,5-dimethoxyphenyl)- [1,2,4]tria...)
Affinity DataIC50: 0.700nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558592((4-((6-(2-chloro-3,5-dimethoxyphenyl)- [1,2,4]tria...)
Affinity DataIC50: 6.20nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558592((4-((6-(2-chloro-3,5-dimethoxyphenyl)- [1,2,4]tria...)
Affinity DataIC50: 98nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent