BDBM558587 N-(4-(3,8-diazabicyclo[3.2.1]octan-3-yl) phenyl)-6-(2-chloro-3,5-dimethoxy- phenyl)-[1,2,4]triazolo[4',3':1,6]pyrido[2, 3-d]pyrimidin-2-amine::US11365196, Compound 51

SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(Nc3ccc(cc3)N3CC4CCC(C3)N4)nc2n2cnnc12

InChI Key InChIKey=MMGQNXDEDNEWDN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 558587   

TargetFibroblast growth factor receptor 1(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558587(N-(4-(3,8-diazabicyclo[3.2.1]octan-3-yl) phenyl)-6...)
Affinity DataIC50: 0.400nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558587(N-(4-(3,8-diazabicyclo[3.2.1]octan-3-yl) phenyl)-6...)
Affinity DataIC50: 2.40nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558587(N-(4-(3,8-diazabicyclo[3.2.1]octan-3-yl) phenyl)-6...)
Affinity DataIC50: 42nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent