BDBM558576 6-(2-chloro-3,5-dimethoxyphenyl)- N-(4-(4-morpholinopiperidin-1-yl) phenyl)-[1,2,4]triazolo[4',3':1,6] pyrido[2,3-d]pyrimidin-2-amine::US11365196, Compound 29

SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(Nc3ccc(cc3)N3CCC(CC3)N3CCOCC3)nc2n2cnnc12

InChI Key InChIKey=XEYLVQLYTVTEMZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 558576   

TargetFibroblast growth factor receptor 1(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558576(6-(2-chloro-3,5-dimethoxyphenyl)- N-(4-(4-morpholi...)
Affinity DataIC50: 0.800nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558576(6-(2-chloro-3,5-dimethoxyphenyl)- N-(4-(4-morpholi...)
Affinity DataIC50: 1.20nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558576(6-(2-chloro-3,5-dimethoxyphenyl)- N-(4-(4-morpholi...)
Affinity DataIC50: 1.70nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558576(6-(2-chloro-3,5-dimethoxyphenyl)- N-(4-(4-morpholi...)
Affinity DataIC50: 2.90nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558576(6-(2-chloro-3,5-dimethoxyphenyl)- N-(4-(4-morpholi...)
Affinity DataIC50: 21nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent