BDBM557907 1-(3-((4-((4-chloro-3-cyclo- propylphenyl)amino)- pyrido[3,4-d]pyrimidin-6- yl)oxy)azetidin-1-yl)prop-2- en-1-one::US11365189, Ex. No. 62

SMILES Clc1ccc(Nc2ncnc3cnc(OC4CN(C4)C(=O)C=C)cc23)cc1C1CC1

InChI Key InChIKey=HHBFNITYFSGXHZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 557907   

TargetEpidermal growth factor receptor(Human)
University Of Texas

US Patent
LigandPNGBDBM557907(US11365189, Ex. No. 62 | 1-(3-((4-((4-chloro-3-cyc...)
Affinity DataIC50: 3.50E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
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TargetEpidermal growth factor receptor [S768I](Human)
University Of Texas

US Patent
LigandPNGBDBM557907(US11365189, Ex. No. 62 | 1-(3-((4-((4-chloro-3-cyc...)
Affinity DataIC50: 2.50E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557907(US11365189, Ex. No. 62 | 1-(3-((4-((4-chloro-3-cyc...)
Affinity DataIC50: 2.10E+4nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557907(US11365189, Ex. No. 62 | 1-(3-((4-((4-chloro-3-cyc...)
Affinity DataIC50: 7.10E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-769,'SVD',770-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557907(US11365189, Ex. No. 62 | 1-(3-((4-((4-chloro-3-cyc...)
Affinity DataIC50: 1.00E+4nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-769,'SV',770-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557907(US11365189, Ex. No. 62 | 1-(3-((4-((4-chloro-3-cyc...)
Affinity DataIC50: 5.40E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent