BDBM557901 1-(3-((4-((4-chloro-3- (hydroxymethyl)phenyl)- amino)-7-methoxy- quinazolin-6-yl)oxy)- pyrrolidin-1-yl)prop-2-en-1- one::US11365189, Ex. No. 55

SMILES COc1cc2ncnc(Nc3ccc(Cl)c(CO)c3)c2cc1OC1CCN(C1)C(=O)C=C

InChI Key InChIKey=QUXNYFVAFUPMHQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 557901   

TargetEpidermal growth factor receptor(Human)
University Of Texas

US Patent
LigandPNGBDBM557901(US11365189, Ex. No. 55 | 1-(3-((4-((4-chloro-3- (h...)
Affinity DataIC50: 1.10E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [S768I](Human)
University Of Texas

US Patent
LigandPNGBDBM557901(US11365189, Ex. No. 55 | 1-(3-((4-((4-chloro-3- (h...)
Affinity DataIC50: 210nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557901(US11365189, Ex. No. 55 | 1-(3-((4-((4-chloro-3- (h...)
Affinity DataIC50: 780nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557901(US11365189, Ex. No. 55 | 1-(3-((4-((4-chloro-3- (h...)
Affinity DataIC50: 600nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-769,'SVD',770-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557901(US11365189, Ex. No. 55 | 1-(3-((4-((4-chloro-3- (h...)
Affinity DataIC50: 870nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-769,'SV',770-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557901(US11365189, Ex. No. 55 | 1-(3-((4-((4-chloro-3- (h...)
Affinity DataIC50: 3.70E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent