BDBM557882 6-((1-acryloylpiperidin-4- yl)oxy)-4-((3-chloro-4- (trifluoromethoxy)phenyl)- amino)-7-methoxy- quinoline-3-carbonitrile::US11365189, Ex. No. 17

SMILES COc1cc2ncc(C#N)c(Nc3ccc(OC(F)(F)F)c(Cl)c3)c2cc1OC1CCN(CC1)C(=O)C=C

InChI Key InChIKey=NKPCMNDXYJEXQJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 557882   

TargetEpidermal growth factor receptor(Human)
University Of Texas

US Patent
LigandPNGBDBM557882(US11365189, Ex. No. 17 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 130nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
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TargetEpidermal growth factor receptor [S768I](Human)
University Of Texas

US Patent
LigandPNGBDBM557882(US11365189, Ex. No. 17 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 95nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557882(US11365189, Ex. No. 17 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557882(US11365189, Ex. No. 17 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 70nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-769,'SVD',770-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557882(US11365189, Ex. No. 17 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-769,'SV',770-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557882(US11365189, Ex. No. 17 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 1.00E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent