BDBM557857 6-((1-acryloylpiperidin-4- yl)oxy)-4-((2,4-dichloro- phenyl)amino)-7-methoxy- quinoline-3-carbonitrile::US11365189, Ex. No. 13

SMILES COc1cc2ncc(C#N)c(Nc3ccc(Cl)cc3Cl)c2cc1OC1CCN(CC1)C(=O)C=C

InChI Key InChIKey=PDNGEGTVMHEBRI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 557857   

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
University Of Texas

US Patent
LigandPNGBDBM557857(US11365189, Ex. No. 13 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 140nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2 [1-780,'GSP',781-1255](Human)
University Of Texas

US Patent
LigandPNGBDBM557857(US11365189, Ex. No. 13 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 20nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent