BDBM557856 6-((1-acryloylpiperidin-4- yl)oxy)-4-((3-(hydroxy- methyl)phenyl)amino)-7- methoxyquinoline-3- carbonitrile::US11365189, Ex. No. 12

SMILES COc1cc2ncc(C#N)c(Nc3cccc(CO)c3)c2cc1OC1CCN(CC1)C(=O)C=C

InChI Key InChIKey=UMDSDVLGWVPCHN-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 557856   

TargetReceptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255](Human)
University Of Texas

US Patent
LigandPNGBDBM557856(US11365189, Ex. No. 12 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 4.50E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2 [1-780,'GSP',781-1255](Human)
University Of Texas

US Patent
LigandPNGBDBM557856(US11365189, Ex. No. 12 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 260nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
University Of Texas

US Patent
LigandPNGBDBM557856(US11365189, Ex. No. 12 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 1.00E+4nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [S768I](Human)
University Of Texas

US Patent
LigandPNGBDBM557856(US11365189, Ex. No. 12 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 650nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-770,'SVD',771-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557856(US11365189, Ex. No. 12 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 2.70E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557856(US11365189, Ex. No. 12 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 2.30E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-769,'SVD',770-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557856(US11365189, Ex. No. 12 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 3.90E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-769,'SV',770-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557856(US11365189, Ex. No. 12 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 1.00E+4nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [1-772,'NPH',773-1210](Human)
University Of Texas

US Patent
LigandPNGBDBM557856(US11365189, Ex. No. 12 | 6-((1-acryloylpiperidin-4...)
Affinity DataIC50: 2.60E+3nMAssay Description:Cell viability was determined using the Cell Titer Glo assay (Promega) as previously described. Briefly, 2000-3000 cells per well were plated in 384-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent