BDBM557837 1-[4-[5-[5-[(6-isopropylpyrazin-2-yl)amino]-1-methyl-pyrazol-4-yl]pyrazin-2-yl]phenyl]cyclopropanecarboxylic Acid; Hydrochloride::US11365185, Example 19B

SMILES CC(C)c1cncc(Nc2c(cnn2C)-c2cnc(cn2)-c2ccc(cc2)C2(CC2)C(O)=O)n1

InChI Key InChIKey=PTNUTYVOMANMRW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 557837   

TargetLysophosphatidic acid receptor 1(Human)
Eli Lilly

US Patent
LigandPNGBDBM557837(US11365185, Example 19B | 1-[4-[5-[5-[(6-isopropyl...)
Affinity DataIC50: 88.1nMAssay Description:A cDNA encoding the human LPAR1 receptor is synthesized and cloned into pDNA3 expression plasmid. The plasmid is transfected in U937 cells using Lipo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetLysophosphatidic acid receptor 3(Human)
Eli Lilly

US Patent
LigandPNGBDBM557837(US11365185, Example 19B | 1-[4-[5-[5-[(6-isopropyl...)
Affinity DataIC50: 2.40E+3nMAssay Description:A cDNA encoding the human LPAR3 receptor is synthesized and cloned into pDNA3 expression plasmid. The plasmid is transfected in U2OS cells using Lipo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent