BDBM557827 1-[2-cyano-4-[6-[5-[[6-(cyclopropoxy)pyrazin-2-yl]amino]-1-methyl-pyrazol-4-yl]-3-pyridyl]phenyl]cyclopropanecarboxylic Acid; Hydrochloride::US11365185, Example 9B

SMILES Cn1ncc(c1Nc1cncc(OC2CC2)n1)-c1ccc(cn1)-c1ccc(c(c1)C#N)C1(CC1)C(O)=O

InChI Key InChIKey=KOIJODABUPRJDS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 557827   

TargetLysophosphatidic acid receptor 1(Human)
Eli Lilly

US Patent
LigandPNGBDBM557827(US11365185, Example 9B | 1-[2-cyano-4-[6-[5-[[6-(c...)
Affinity DataIC50: 17.9nMAssay Description:A cDNA encoding the human LPAR1 receptor is synthesized and cloned into pDNA3 expression plasmid. The plasmid is transfected in U937 cells using Lipo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetLysophosphatidic acid receptor 3(Human)
Eli Lilly

US Patent
LigandPNGBDBM557827(US11365185, Example 9B | 1-[2-cyano-4-[6-[5-[[6-(c...)
Affinity DataIC50: 1.00E+4nMAssay Description:A cDNA encoding the human LPAR3 receptor is synthesized and cloned into pDNA3 expression plasmid. The plasmid is transfected in U2OS cells using Lipo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent