BDBM557789 (1S,3'R,6'R,7'S,10'S,11'S)-6-chloro-7'-(cis-5- (dimethylamino)-1,3-dioxan-2-yl)-10',11'- dimethyl-3,4-dihydro-2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14]diazatetracyclo [14.7.2.0~3,6~.0~19,24~]pentacosa[16,18,24] trien]-15'-one 13',13'-dioxide OR::US11364248, Example 84::US11364248, Example 85

SMILES C[C@H]1CC[C@@H]([C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)C[C@H]1C)[C@@H]1OC[C@@H](CO1)N(C)C

InChI Key InChIKey=WWTNGBQQCAJYLW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 557789   

LigandPNGBDBM557789(US11364248, Example 85 | (1S,3'R,6'R,7'S,10'S,11'S...)
Affinity DataIC50: 0.331nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
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Date in BDB:
9/25/2022
Entry Details
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LigandPNGBDBM557789(US11364248, Example 85 | (1S,3'R,6'R,7'S,10'S,11'S...)
Affinity DataIC50: 2.06nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent