BDBM557713 (1S,3'R,6'R,7'R,11'S,12'R)-6-chloro-11',12'- dimethyl-7'-((2r,3aR,6aS)-tetrahydro-3aH- [1,3]dioxolo[4,5-c]pyrrol-2-yl)-3,4-dihydro- 2H,15'H-spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14]diazatetracyclo [14.7.2.0~3,6~.0~19,24~]pentacosa[16,18,24] trien]-15'-one 13',13'-dioxide OR::US11364248, Example 10::US11364248, Example 15::US11364248, Example 35::US11364248, Example 9

SMILES C[C@H]1CCC[C@@H]([C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C)[C@@H]1O[C@@H]2CNC[C@@H]2O1

InChI Key InChIKey=HBQXQBNAQLMKNC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 557713   

LigandPNGBDBM557713(US11364248, Example 35 | US11364248, Example 15 | ...)
Affinity DataIC50: 0.490nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
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Date in BDB:
9/25/2022
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LigandPNGBDBM557713(US11364248, Example 35 | US11364248, Example 15 | ...)
Affinity DataIC50: 1.27nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
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LigandPNGBDBM557713(US11364248, Example 35 | US11364248, Example 15 | ...)
Affinity DataIC50: 0.765nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

LigandPNGBDBM557713(US11364248, Example 35 | US11364248, Example 15 | ...)
Affinity DataIC50: 0.829nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent