BDBM556519 N-(-2-aminophenyl)-2-((2-4(((2-(4-flurophenyl)cyclopropyl)amino)methyl)piperdine-1-yl)ethyl)amino)pyrimidine-5-carboxamide TFA Salt::US11352322, Compound 150

SMILES Nc1ccccc1NC(=O)c1cnc(NCCN2CCC(CNC3CC3c3ccc(F)cc3)CC2)nc1

InChI Key InChIKey=USZPNMJCBOVESU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 556519   

TargetLysine-specific histone demethylase 1A(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM556519(US11352322, Compound 150 | N-(-2-aminophenyl)-2-((...)
Affinity DataIC50: 16nMAssay Description:LSD1 enzyme was produced in house. Tranylcypromine (TCP), LSD1 inhibitor was procured from Selleckchem. LSD1 enzyme, TCP and Biotinylated peptide sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetHistone deacetylase 6(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM556519(US11352322, Compound 150 | N-(-2-aminophenyl)-2-((...)
Affinity DataIC50: 1.00E+4nMAssay Description:Histone deacetylase assay was done as per manufacturer's instructions. Briefly, assay buffer, 200 uM HDAC substrate (fluorogenic HDAC acetylated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent