BDBM556489 (E)-N-hydroxy-4-(3-(3-(((2-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)cyclopropyl)amino)methyl)azetidin-1-yl)-3-oxoprop-1-en-1-yl)benzamide TFA Salt::US11352322, Compound 119

SMILES Cn1cc(cn1)-c1ccc(cc1)C1CC1NCC1CN(C1)C(=O)\C=C\c1ccc(cc1)C(=O)NO

InChI Key InChIKey=XNOVADVADHFJFS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 556489   

TargetLysine-specific histone demethylase 1A(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM556489(US11352322, Compound 119 | (E)-N-hydroxy-4-(3-(3-(...)
Affinity DataIC50: 19nMAssay Description:LSD1 enzyme was produced in house. Tranylcypromine (TCP), LSD1 inhibitor was procured from Selleckchem. LSD1 enzyme, TCP and Biotinylated peptide sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetHistone deacetylase 6(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM556489(US11352322, Compound 119 | (E)-N-hydroxy-4-(3-(3-(...)
Affinity DataIC50: 49nMAssay Description:Histone deacetylase assay was done as per manufacturer's instructions. Briefly, assay buffer, 200 uM HDAC substrate (fluorogenic HDAC acetylated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent