BDBM556467 5-(2-(((1R,2S)-2-(4-fluorophenyl)cyclopropyl)amino)acetyl)-N-hydroxy-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxamide TFA Salt::US11352322, Compound 103A

SMILES ONC(=O)c1cc2CN(CCc2s1)C(=O)CN[C@@H]1C[C@H]1c1ccc(F)cc1

InChI Key InChIKey=CXOBQIPLKMWRGP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 556467   

TargetLysine-specific histone demethylase 1A(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM556467(US11352322, Compound 103A | 5-(2-(((1R,2S)-2-(4-fl...)
Affinity DataIC50: 667nMAssay Description:LSD1 enzyme was produced in house. Tranylcypromine (TCP), LSD1 inhibitor was procured from Selleckchem. LSD1 enzyme, TCP and Biotinylated peptide sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM556467(US11352322, Compound 103A | 5-(2-(((1R,2S)-2-(4-fl...)
Affinity DataIC50: 22nMAssay Description:Histone deacetylase assay was done as per manufacturer's instructions. Briefly, assay buffer, 200 uM HDAC substrate (fluorogenic HDAC acetylated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent