BDBM556414 N-hydroxy-4-(3-(4-(((2-(4-(6-(trifluoromethyl)pyridin-3-yl)phenyl)cyclopropyl)amino)methyl)piperidin-1-yl)propyl)benzamide TFA Salt::US11352322, Compound 66

SMILES ONC(=O)c1ccc(CCCN2CCC(CNC3CC3c3ccc(cc3)-c3ccc(nc3)C(F)(F)F)CC2)cc1

InChI Key InChIKey=VPZPSTHUSDFUKN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 556414   

TargetLysine-specific histone demethylase 1A(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM556414(US11352322, Compound 66 | N-hydroxy-4-(3-(4-(((2-(...)
Affinity DataIC50: 19nMAssay Description:LSD1 enzyme was produced in house. Tranylcypromine (TCP), LSD1 inhibitor was procured from Selleckchem. LSD1 enzyme, TCP and Biotinylated peptide sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetHistone deacetylase 6(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM556414(US11352322, Compound 66 | N-hydroxy-4-(3-(4-(((2-(...)
Affinity DataIC50: 100nMAssay Description:Histone deacetylase assay was done as per manufacturer's instructions. Briefly, assay buffer, 200 uM HDAC substrate (fluorogenic HDAC acetylated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent