BDBM556405 N-hydroxy-4-(3-(4-(((2-(4-(pyrimidin-5-yl)phenyl)cyclopropyl)amino)methyl)piperidin-1-yl)propyl)benzamide TFA Salt::US11352322, Compound 61

SMILES ONC(=O)c1ccc(CCCN2CCC(CNC3CC3c3ccc(cc3)-c3cncnc3)CC2)cc1

InChI Key InChIKey=HOJXWPCFCRGBLU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 556405   

TargetLysine-specific histone demethylase 1A(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM556405(US11352322, Compound 61 | N-hydroxy-4-(3-(4-(((2-(...)
Affinity DataIC50: 12nMAssay Description:LSD1 enzyme was produced in house. Tranylcypromine (TCP), LSD1 inhibitor was procured from Selleckchem. LSD1 enzyme, TCP and Biotinylated peptide sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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TargetHistone deacetylase 6(Human)
Jubilant Epicore

US Patent
LigandPNGBDBM556405(US11352322, Compound 61 | N-hydroxy-4-(3-(4-(((2-(...)
Affinity DataIC50: 121nMAssay Description:Histone deacetylase assay was done as per manufacturer's instructions. Briefly, assay buffer, 200 uM HDAC substrate (fluorogenic HDAC acetylated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent