BDBM556064 1-((3S,5R)-1-Acryloyl-5-(methoxymethyl)pyrrolidin-3-yl-3-((6-fluoro-1-isopropyl-1H-benzo[d]imidazol-5-yl)ethynyl)-5-(methylamino)-1H-pyrazole-4-carboxamide::US11345681, Example 237

SMILES CNc1c(C(N)=O)c(nn1[C@H]1C[C@H](COC)N(C1)C(=O)C=C)C#Cc1cc2ncn(C(C)C)c2cc1F

InChI Key InChIKey=VRWGJEGSNQCDOR-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 556064   

TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 100nMAssay Description:Small molecule inhibition of FGFR2 kinase activity was evaluated using a fluorescence-based microfluidic mobility shift assay. FGFR2 catalyzes the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 2.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 54nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 5.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed