BDBM555966 3-[2-(1-Cyclopropyl-6-fluoro-1,3-benzodiazol-5-yl)ethynyl]-1-[(3S,5R)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)pyrazole-4-carboxamide::US11345681, Example 135::US11345681, Example 167

SMILES CNc1c(C(N)=O)c(nn1[C@H]1C[C@H](COC)N(C1)C(=O)C=C)C#Cc1cc2ncn(C3CC3)c2cc1F

InChI Key InChIKey=AVUXLVYBASDKOX-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 555966   

TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM555966(3-[2-(1-Cyclopropyl-6-fluoro-1,3-benzodiazol-5-yl)...)
Affinity DataIC50: 100nMAssay Description:Small molecule inhibition of FGFR2 kinase activity was evaluated using a fluorescence-based microfluidic mobility shift assay. FGFR2 catalyzes the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM555966(3-[2-(1-Cyclopropyl-6-fluoro-1,3-benzodiazol-5-yl)...)
Affinity DataIC50: 100nMAssay Description:Small molecule inhibition of FGFR2 kinase activity was evaluated using a fluorescence-based microfluidic mobility shift assay. FGFR2 catalyzes the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555966(3-[2-(1-Cyclopropyl-6-fluoro-1,3-benzodiazol-5-yl)...)
Affinity DataIC50: 2.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM555966(3-[2-(1-Cyclopropyl-6-fluoro-1,3-benzodiazol-5-yl)...)
Affinity DataIC50: 3.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM555966(3-[2-(1-Cyclopropyl-6-fluoro-1,3-benzodiazol-5-yl)...)
Affinity DataIC50: 13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM555966(3-[2-(1-Cyclopropyl-6-fluoro-1,3-benzodiazol-5-yl)...)
Affinity DataIC50: 6.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555966(3-[2-(1-Cyclopropyl-6-fluoro-1,3-benzodiazol-5-yl)...)
Affinity DataIC50: 9.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555966(3-[2-(1-Cyclopropyl-6-fluoro-1,3-benzodiazol-5-yl)...)
Affinity DataIC50: 16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555966(3-[2-(1-Cyclopropyl-6-fluoro-1,3-benzodiazol-5-yl)...)
Affinity DataIC50: 3.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed