BDBM555838 1-((3S,5R)-1-acryloyl-5-(methoxymethyl)pyrrolidin-3-yl)-3-((1-ethyl-1H-benzo[d]imidazol-5-yl)ethynyl)-5-(methylamino)-1H-pyrazole-4-carboxamide::US11345681, Example 6

SMILES CCn1cnc2cc(ccc12)C#Cc1nn([C@H]2C[C@H](COC)N(C2)C(=O)C=C)c(NC)c1C(N)=O

InChI Key InChIKey=RUUWTDVRBGAQCD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 555838   

TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM555838(US11345681, Example 6 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 100nMAssay Description:Small molecule inhibition of FGFR2 kinase activity was evaluated using a fluorescence-based microfluidic mobility shift assay. FGFR2 catalyzes the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555838(US11345681, Example 6 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 4.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM555838(US11345681, Example 6 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 4.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM555838(US11345681, Example 6 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM555838(US11345681, Example 6 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 24nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555838(US11345681, Example 6 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 3.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555838(US11345681, Example 6 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 129nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555838(US11345681, Example 6 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 11nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed