BDBM555837 1-((3S,5R)-1-acryloyl-5-(methoxymethyl)pyrrolidin-3-yl)-3-((1,2-dimethyl-1H-benzo[d]imidazol-5-yl)ethynyl)-5-(methylamino)-1H-pyrazole-4-carboxamide::US11345681, Example 5

SMILES CNc1c(C(N)=O)c(nn1[C@H]1C[C@H](COC)N(C1)C(=O)C=C)C#Cc1ccc2n(C)c(C)nc2c1

InChI Key InChIKey=KNPLSRBVKFTLQU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 555837   

TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM555837(US11345681, Example 5 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 100nMAssay Description:Small molecule inhibition of FGFR2 kinase activity was evaluated using a fluorescence-based microfluidic mobility shift assay. FGFR2 catalyzes the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555837(US11345681, Example 5 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 3.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM555837(US11345681, Example 5 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 3.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM555837(US11345681, Example 5 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 37nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555837(US11345681, Example 5 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555837(US11345681, Example 5 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Kinnate Biopharma

Curated by ChEMBL
LigandPNGBDBM555837(US11345681, Example 5 | 1-((3S,5R)-1-acryloyl-5-(m...)
Affinity DataIC50: 22nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed