BDBM555727 US11345676, Compound 1-223::US11345676, Example 23

SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cc(Oc3cccc(n3)C(F)(F)F)ccc2F)c1

InChI Key InChIKey=GXTRZDRVMPWSIX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 555727   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Pharmakea

US Patent
LigandPNGBDBM555727(US11345676, Example 23 | US11345676, Compound 1-22...)
Affinity DataIC50: 300nMAssay Description:Table 3: The ability of test compounds to inhibit ASK1 kinase activity was determined using the luminescent ADP-Glo Kinase Assay and Myelin Basic Pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent