BDBM555726 US11345676, Compound 2-1::US11345676, Example 22

SMILES NCc1cc(Oc2ccnc(c2)C(=O)Nc2cccc(c2)-c2nncn2C2CC2)nc(c1)C(F)(F)F

InChI Key InChIKey=FUVPMLHOJDWGLW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 555726   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Pharmakea

US Patent
LigandPNGBDBM555726(US11345676, Example 22 | US11345676, Compound 2-1)
Affinity DataIC50: 1.00E+3nMAssay Description:Table 3: The ability of test compounds to inhibit ASK1 kinase activity was determined using the luminescent ADP-Glo Kinase Assay and Myelin Basic Pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
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TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM555726(US11345676, Example 22 | US11345676, Compound 2-1)
Affinity DataIC50: 300nMAssay Description:Table 4: LOXL2 amine oxidase activity was evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media from CHO cells s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent