BDBM555723 US11345676, Compound 1-331::US11345676, Example 19

SMILES CC(C)n1cnnc1-c1cccc(NC(=O)c2cccc(Oc3cc(CN)cc(n3)C(F)(F)F)c2)n1

InChI Key InChIKey=FUWBYZGDIOXBHN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 555723   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Pharmakea

US Patent
LigandPNGBDBM555723(US11345676, Example 19 | US11345676, Compound 1-33...)
Affinity DataIC50: 300nMAssay Description:Table 3: The ability of test compounds to inhibit ASK1 kinase activity was determined using the luminescent ADP-Glo Kinase Assay and Myelin Basic Pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
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TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM555723(US11345676, Example 19 | US11345676, Compound 1-33...)
Affinity DataIC50: 300nMAssay Description:Table 4: LOXL2 amine oxidase activity was evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media from CHO cells s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent