BDBM555294 34(6-chloro-2-cyclopropyl-1-(1-(ethyl-d5)-1H-pyrazol-4-yl)-7-fluoro-1H-indol-3-yl)thio)-2-fluorobenzoic acid ::BDBM50540913::US11344533, Compound 1-127

SMILES CCn1cc(cn1)-n1c(C2CC2)c(Sc2cccc(C(O)=O)c2F)c2ccc(Cl)c(F)c12

InChI Key InChIKey=BQMMCRXYIIKAOB-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 555294   

TargetAutotaxin(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM555294(BDBM50540913 | 34(6-chloro-2-cyclopropyl-1-(1-(eth...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human ATX by LPC choline release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetAutotaxin(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM555294(BDBM50540913 | 34(6-chloro-2-cyclopropyl-1-(1-(eth...)
Affinity DataIC50: 500nMAssay Description:ATX activity is assayed in concentrated conditioned media from Hep3B human hepatocellular carcinoma cells by measuring the amount of choline released...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM555294(BDBM50540913 | 34(6-chloro-2-cyclopropyl-1-(1-(eth...)
Affinity DataIC50: 500nMAssay Description:ATX activity is assayed in concentrated conditioned media from Hep3B human hepatocellular carcinoma cells by measuring the amount of choline released...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM555294(BDBM50540913 | 34(6-chloro-2-cyclopropyl-1-(1-(eth...)
Affinity DataIC50: 500nMAssay Description:ATX activity is assayed in concentrated conditioned media from Hep3B human hepatocellular carcinoma cells by measuring the amount of choline released...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM555294(BDBM50540913 | 34(6-chloro-2-cyclopropyl-1-(1-(eth...)
Affinity DataIC50: 2nMAssay Description:Inhibition of ATX (unknown origin) using lysoPLD as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetAutotaxin(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM555294(BDBM50540913 | 34(6-chloro-2-cyclopropyl-1-(1-(eth...)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of ATX in human bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Mouse)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM555294(BDBM50540913 | 34(6-chloro-2-cyclopropyl-1-(1-(eth...)
Affinity DataIC50: 62nMAssay Description:Inhibition of ATX in mouse plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed