BDBM555111 2-{3-[2-(dimethylamino)ethoxy]pyridin-4-yl}-3-[(3-fluorophenyl)amino]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one::US11339157, Example 5

SMILES CN(C)CCOc1cnccc1-c1[nH]c2CCNC(=O)c2c1Nc1cccc(F)c1

InChI Key InChIKey=ZCTDWNWCKSRZLM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 555111   

TargetEpidermal growth factor receptor [669-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM555111(US11339157, Example 5 | 2-{3-[2-(dimethylamino)eth...)
Affinity DataIC50: 1.56nMAssay Description:Exon 20-Mutant-EGFR(D770_N771insSVD): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2022
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [669-770,'SVD',771-1210](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM555111(US11339157, Example 5 | 2-{3-[2-(dimethylamino)eth...)
Affinity DataIC50: 4.31nMAssay Description:Exon 20-Mutant-EGFR(V769_D770insASV): For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into either a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2022
Entry Details
Go to US Patent