BDBM553002 N-(6-fluoro-3'- (morpholinomethyl)-4- ((3R,5S)-3,4,5- trimethylpiperazin-1-yl)- [1,1-biphenyl]-3-yl)-6- oxo-4-(trifluoromethyl)- 1,6-dihydropyridine-3- carboxamide::US11319299, Example 52

SMILES C[C@H]1CN(C[C@@H](C)N1C)c1cc(F)c(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cccc(CN2CCOCC2)c1

InChI Key InChIKey=SSOACIZIDUEFOJ-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 553002   

TargetMLL1-WRAD2 complex(Human)
Propellon Therapeutics

US Patent
LigandPNGBDBM553002(N-(6-fluoro-3'- (morpholinomethyl)-4- ((3R,5S)-3,4...)
Affinity DataIC50: 1.28E+3nMAssay Description:Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
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TargetWD repeat-containing protein 5(Human)
Propellon Therapeutics

US Patent
LigandPNGBDBM553002(N-(6-fluoro-3'- (morpholinomethyl)-4- ((3R,5S)-3,4...)
Affinity DataKd:  6nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent