BDBM552963 N-[4-fluoro-2-(4- methylpiperazin-1-yl)-5- [2-(2,2,2-trifluoroethoxy) pyrimidin-5-yl]phenyl]-6- oxo-4-(trifluoromethyl)-1H- pyridine-3-carboxamide::US11319299, Example 17

SMILES CN1CCN(CC1)c1cc(F)c(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cnc(OCC(F)(F)F)nc1

InChI Key InChIKey=YIGUOFOBBBPQLX-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 552963   

TargetMLL1-WRAD2 complex(Human)
Propellon Therapeutics

US Patent
LigandPNGBDBM552963(N-[4-fluoro-2-(4- methylpiperazin-1-yl)-5- [2-(2,2...)
Affinity DataIC50: 2.07E+3nMAssay Description:Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
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TargetWD repeat-containing protein 5(Human)
Propellon Therapeutics

US Patent
LigandPNGBDBM552963(N-[4-fluoro-2-(4- methylpiperazin-1-yl)-5- [2-(2,2...)
Affinity DataKd:  6nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent