BDBM552932 4-fluoro-N-[4-fluoro-2- (4-methylpiperazin-1-yl)- 5-[3-(morpholin-4- ylmethyl)phenyl]phenyl]- 3,5-dimethylbenzamide::US11319299, Example 1

SMILES CN1CCN(CC1)c1cc(F)c(cc1NC(=O)c1cc(C)c(F)c(C)c1)-c1cccc(CN2CCOCC2)c1

InChI Key InChIKey=PXTYRLCEWAUNKF-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 552932   

TargetMLL1-WRAD2 complex(Human)
Propellon Therapeutics

US Patent
LigandPNGBDBM552932(4-fluoro-N-[4-fluoro-2- (4-methylpiperazin-1-yl)- ...)
Affinity DataIC50: 1.50E+4nMAssay Description:Compound potency was assessed through incorporation of 3H-SAM into oligonucleosomes purified from HeLa cells. Specifically, recombinant human MLL1 (a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
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TargetWD repeat-containing protein 5(Human)
Propellon Therapeutics

US Patent
LigandPNGBDBM552932(4-fluoro-N-[4-fluoro-2- (4-methylpiperazin-1-yl)- ...)
Affinity DataKd:  84nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent