BDBM552826 (R)-3-(3-(2-(7H-Pyrrolo[2,3-b]pyrimidin-5-yl)thiazol-4-yl)phenyl)-3-hydroxy- 1 -methylpyrrolidin-2-one.::WO2022104348, Example 53

SMILES CN1CC[C@](O)(C1=O)c1cccc(c1)-c1csc(n1)-c1c[nH]c2ncncc12

InChI Key InChIKey=JBJPRQZKFDIZDY-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 552826   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Janssen Pharmaceutica

WIPO

LigandBDBM552826((R)-3-(3-(2-(7H-Pyrrolo[2,3-b]pyrimidin-5-yl)thiaz...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreen (ascreen) format (Perkin Elmer). All compound6 tested were dissolved in ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
8/7/2022
Entry Details
Copy BDB DOIWIPO WO2022104348

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