BDBM552822 (R)-3-Hydroxy-3-(3-(2-(5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)thiazol-4-yl)phenyl)-1-methylpyrrolidin-2-one.::WO2022104348, Example 49

SMILES COc1cnc2[nH]cc(-c3nc(cs3)-c3cccc(c3)[C@]3(O)CCN(C)C3=O)c2c1

InChI Key InChIKey=DPKZXZDMVQPKIA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 552822   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Janssen Pharmaceutica

WIPO
LigandPNGBDBM552822((R)-3-Hydroxy-3-(3-(2-(5-methoxy-1H-pyrrolo[2,3-b]...)
Affinity DataIC50: 100nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreen (ascreen) format (Perkin Elmer). All compound6 tested were dissolved in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104348