BDBM552786 (R)-7-(3-(2-(5H-Pyrrolo[2,3-b]pyrazin-7-yl)thiazol-4-yl)phenyl)-7H-pyrrolo[1,2-a]imidazol-7-ol.::WO2022104348, Example 13::WO2022104348, Example 18::WO2022104348, Example 19

SMILES O[C@@]1(Cc2nccn2C1)c1cccc(c1)-c1csc(n1)-c1c[nH]c2nccnc12

InChI Key InChIKey=AXRTUMRJYUTWDF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 552786   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Janssen Pharmaceutica

WIPO
LigandPNGBDBM552786(WO2022104348, Example 19 | WO2022104348, Example 1...)
Affinity DataIC50: 100nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreen (ascreen) format (Perkin Elmer). All compound6 tested were dissolved in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104348

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Janssen Pharmaceutica

WIPO
LigandPNGBDBM552786(WO2022104348, Example 19 | WO2022104348, Example 1...)
Affinity DataIC50: 500nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreen (ascreen) format (Perkin Elmer). All compound6 tested were dissolved in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104348

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Janssen Pharmaceutica

WIPO
LigandPNGBDBM552786(WO2022104348, Example 19 | WO2022104348, Example 1...)
Affinity DataIC50: 500nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreen (ascreen) format (Perkin Elmer). All compound6 tested were dissolved in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022104348