BDBM552651 WO2022101377, Example 50

SMILES CCC12CC(C1)(C2)NC(=O)[C@@H]1Cc2sc-3c([C@@H](NCc4nnc(C)n-34)c3ccccc3Cl)c2C1

InChI Key InChIKey=MXVBMXMJYXTVHU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 552651   

TargetPlatelet-activating factor receptor(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM552651(WO2022101377, Example 50)
Affinity DataIC50: 0.5nMAssay Description:USING AN ENDPOINT ASSAY HEK293 cells overexpressing human PAFR (produced in-house) are seeded into a Poly-D-Lysine coated 384 well white cell culture...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022101377

TargetPlatelet-activating factor receptor(Human)
Boehringer Ingelheim International

WIPO
LigandPNGBDBM552651(WO2022101377, Example 50)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human PAFR expressed in HEK293 cells assessed as inhibition of PAF C-16 ligand induced receptor activation preincubated for 90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed