BDBM552115 (18*R)-2-fluoro-18-(3-fluorophenyl)-12-hydroxy-6,7,8,9-tetrahydro-18H-10,17-methanobenzo[b]pyrido[1,2-f][1]oxa[5,6,9]triazacyclotridecine-11,13-dione (compound 32A)::US11312727, Compound 32B

SMILES Oc1c2C(=O)N3CN([C@@H](c4cccc(F)c4)c4cc(F)ccc4OCCCC3)n2ccc1=O

InChI Key InChIKey=LNTZWWHCXKYWPR-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 552115   

TargetPolymerase basic protein 2(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Janssen Biopharma

US Patent
LigandPNGBDBM552115((18*R)-2-fluoro-18-(3-fluorophenyl)-12-hydroxy-6,7...)
Affinity DataEC50:  25nMAssay Description:Human lung carcinoma A549 cells (ATCC, Manassas, Va.) were plated at a density of 5×104 cells/mL (10×103 cells/well) in assay media (Ham's F12 me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetPolymerase basic protein 2(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Janssen Biopharma

US Patent
LigandPNGBDBM552115((18*R)-2-fluoro-18-(3-fluorophenyl)-12-hydroxy-6,7...)
Affinity DataIC50: 58nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent