BDBM552113 (19bR,Z)-4-hydroxy-8,9,15,19b-tetrahydro-7H,14H-13,12-(epiprop[1]en[1]yl[3]ylidene)-6,20-methanobenzo[3,4]cyclohepta[1,2-1]pyrido[1,2-b][1,2,5]triazacyclotridecine-3,5-dione ::US11312727, Compound 31B

SMILES Oc1c2C(=O)N3CN([C@@H]4c5ccccc5CCc5cccc(\C=C/CCC3)c45)n2ccc1=O

InChI Key InChIKey=FUAVVRZQPPEGQB-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 552113   

TargetPolymerase basic protein 2(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Janssen Biopharma

US Patent
LigandPNGBDBM552113((19bR,Z)-4-hydroxy-8,9,15,19b-tetrahydro-7H,14H-13...)
Affinity DataEC50:  4nMAssay Description:Human lung carcinoma A549 cells (ATCC, Manassas, Va.) were plated at a density of 5×104 cells/mL (10×103 cells/well) in assay media (Ham's F12 me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetPolymerase basic protein 2(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Janssen Biopharma

US Patent
LigandPNGBDBM552113((19bR,Z)-4-hydroxy-8,9,15,19b-tetrahydro-7H,14H-13...)
Affinity DataIC50: 7nMAssay Description:EN PA FRET inhibition assay was performed using a 19 nucleotide synthetic oligoribonucleotide substrate: 5′-FAM-AUUUUGUUUUUAAUAUUUC-BHQ-3′...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent